Peyman Banooni, MD, FACOG
Dr. Peyman Banooni is a board-certified obstetrician-gynecologist who has practiced in Beverly Hills for over 20 years, with a clinical and research focus on uterine fibroids and minimally invasive gynecologic surgery. He trained at UCLA, UC San Diego School of Medicine, and completed his residency at Cedars-Sinai Medical Center.
Training & Board Certification
Academic Background
B.S., Biology — University of California, Los Angeles (Summa Cum Laude, College Honors, 1995)
M.D. — University of California, San Diego, School of Medicine (1999)
OB/GYN Residency — Cedars-Sinai Medical Center, Chief Resident (completed 2003)
Fellow, American College of Obstetricians and Gynecologists (2006)
Credentials
American Board of Obstetrics & Gynecology, Board Certified
Admitting Privileges — Cedars-Sinai Medical Center
Medical Expert, Medical Board of California (2010–present)
Academic & Institutional Roles
Director, Gynecology Center of Excellence, La Peer Health Systems (2012–present)
Member, Cedars-Sinai Center of Excellence for Minimally Invasive Gynecologic Surgery (2008–present)
Cedars-Sinai Medical Center Peer Review Committee (2017–present)
Secretary, Department of OB/GYN PIC Committee, Cedars-Sinai Medical Center (2023–present)
Affiliations
American Board of Obstetrics & Gynecology
Society of Laparoendoscopic Surgeons
North American Menopause Society
Cedars-Sinai Alumni Association
Mini-Laparotomy Myomectomy
Dr. Banooni is the lead surgeon for mini-laparotomy myomectomy at Cedars-Sinai Medical Center, where he has refined this minimally invasive alternative to laparoscopic and robotic myomectomy — performed through a single 4–5 cm incision rather than multiple port sites, with comparable recovery and often shorter surgical time.
National clinical research in fibroid treatment
Beyond clinical practice, Dr. Banooni has served as principal investigator or sub-investigator on numerous national clinical trials in women's health — including trials evaluating medical treatments specifically for uterine fibroids.
Uterine fibroid clinical trials
Principal investigator, ObsEva S.A. (2017): a Phase 3 study evaluating the efficacy and safety of daily oral therapy, alone and combined with add-back therapy, for heavy menstrual bleeding associated with uterine fibroids in premenopausal women.
Sub-investigator, ObsEva S.A. (2016) and Repros Therapeutics (2015): additional Phase 3 trials evaluating medical treatments for symptomatic uterine fibroids and associated heavy menstrual bleeding.
Peer-reviewed publications
Co-author on multicenter clinical research published in the New England Journal of Medicine, Clinical Infectious Diseases, and the Journal of Infectious Diseases, alongside earlier published research in JAMA and the Journal of Virology.
View Full Research Portfolio
Dr. Banooni has served as a national principal investigator or sub-investigator on more than 50 industry- and institution-sponsored clinical trials since 2012, spanning women's health, contraception, diagnostics, and vaccine research — reflecting a career built on active participation in advancing evidence-based medicine, not just clinical practice alone.
2025
Master protocol evaluating an investigational once-daily oral medication vs. placebo in women with stress urinary incontinence who have obesity or overweight (RESTRAIN-SUI).
Clinical validation of a multiplex respiratory test system in at-home and non-laboratory settings.
Phase 2 dose-finding study of an investigational vaccine's safety, tolerability, and immunogenicity in healthy infants given alongside routine pediatric vaccines.
Two Phase 3 studies evaluating the safety and immunogenicity of investigational vaccines administered concomitantly with routine pediatric vaccines in healthy infants and toddlers.
Phase 3a lot-to-lot consistency study of an investigational varicella vaccine compared with Varivax in healthy children 12–15 months of age.
Clinical validation of a COVID-19 antigen test for point-of-care and at-home (OTC) use.
Multicenter study evaluating the performance of a home-use acetylcholinesterase test system.
Clinical study evaluating digital and early-detection pregnancy test products.
Clinical performance and reproducibility study of the cobas BV/CV molecular diagnostic test.
2024
Phase 3 study of an investigational multivalent norovirus vaccine to prevent acute gastroenteritis in adults 18 and older.
Clinical evaluation of the BD Veritor™ rapid diagnostic testing system.
Phase 1 age de-escalation study of an investigational RSV vaccine in children aged 5 to 24 months.
Phase 3 study comparing an investigational pneumococcal-type vaccine with a 20-valent pneumococcal conjugate vaccine in healthy infants and toddlers.
Clinical evaluation of the ID NOW™ CT/NG diagnostic test.
Phase I study (CORAL) evaluating non-interference of routine pediatric vaccines with an investigational live-attenuated RSV vaccine in infants and toddlers.
Multicenter trial on contraceptive efficacy, safety, and tolerability over 13 cycles.
2023
Multicenter evaluation of point-of-care COVID-19 antigen test performance (two separate studies).
Phase 2 study of an mRNA RSV vaccine in pregnant women and the resulting safety/immunogenicity in their infants.
Sample acquisition and testing protocol supporting development of COVID-19 and influenza antigen tests.
Study evaluating therapeutic equivalence of a low-dose estradiol vaginal insert for dyspareunia related to vulvar and vaginal atrophy.
Clinical study of a rapid syphilis diagnostic test.
Self-collection study for high-risk HPV testing among patients referred to colposcopy.
Multi-country cohort study describing the safety of RSV maternal vaccination across several prior maternal-vaccine studies.
Phase 3 single-arm study evaluating contraceptive efficacy and safety in women of childbearing potential.
Phase II study comparing an investigational MMRV vaccine with ProQuad in children aged 4–6 years.
2022
Phase 3 trial assessing efficacy, safety, and reactogenicity of an RSV vaccine in adults 60 and older.
HSV and VZV swab collection study.
Multi-country study evaluating repeat-dose RSV maternal vaccination during a subsequent pregnancy.
Phase II study comparing vaccine potencies in healthy children during their second year of life.
Phase II/III age- and dose-escalation study of a COVID-19 vaccine candidate in healthy children.
Validation study comparing nasopharyngeal RT-PCR testing with the COVISTIX rapid antigen test.
2021
Validation study comparing nasal COVISTIX testing with nasal RT-PCR.
Specimen collection study supporting high-risk HPV testing in women referred to colposcopy.
Phase I/II safety, immunogenicity, and dose-finding study of an investigational live-attenuated RSV vaccine in infants and toddlers.
ACTIV-6: a national outpatient trial evaluating repurposed medications for COVID-19.
Phase 2/3 study of the BNT162b2 SARS-CoV-2 mRNA vaccine in healthy pregnant women.
Adaptive platform trial evaluating antithrombotic strategies in non-hospitalized adults with COVID-19.
2020
Phase 3 study assessing contraceptive efficacy and safety of the etonogestrel implant during extended use beyond 3 years.
Phase III study of an unadjuvanted RSV maternal vaccine in pregnant women and their infants.
Phase 3 efficacy trial (EVOGUARD) of a vaginal gel for prevention of chlamydia and gonorrhea infection.
Clinical evaluation of the investigational ID NOW™ COVID-19 assay, and a related specimen-collection protocol.
Performance assessment of the STANDARD Q COVID-19 antigen test.
Phase II safety and immunogenicity study of a pneumococcal conjugate vaccine given with routine pediatric vaccines.
Phase 3 trial evaluating an RSV vaccine's efficacy and safety in infants born to vaccinated mothers.
2015–2019
Phase 3 study assessing efficacy and safety of treatment for moderate-to-severe endometriosis-associated pain.
ACCESS study evaluating self-selection and use of a continuous-dose oral contraceptive.
Two Phase II studies of RSV vaccines in pregnant women and their infants.
Phase 3 study of an oral treatment for recurrent vulvovaginal candidiasis.
Cohort study comparing outcomes of hysteroscopic (Essure®) vs. laparoscopic tubal sterilization, and a study of extended-use Mirena including a heavy-menstrual-bleeding subgroup.
Clinical performance study of cobas HPV and CINtec® PLUS cytology testing for high-grade cervical disease detection.
Fibroid trial: Phase 3 study of daily oral therapy, alone and with add-back therapy, for heavy menstrual bleeding associated with uterine fibroids in premenopausal women.
Phase 3 study of an RSV nanoparticle vaccine in third-trimester pregnant women and their infants.
Fibroid trial: Phase 3 study of linzagolix (OBE2109), alone and with add-back therapy, for heavy menstrual bleeding associated with uterine fibroids.
Dose-ranging study evaluating an investigational treatment for moderate-to-severe vasomotor symptoms in postmenopausal women.
Fibroid trial: Phase III study of Proellex® (CDB-4124) for the treatment of symptomatic uterine fibroids in premenopausal women.
Study evaluating prevention of endometrial hyperplasia and osteoporosis in postmenopausal women.
2012
Phase 3 study of oral therapy for dysfunctional uterine bleeding.
Comparison of a novel intravenous iron preparation vs. oral iron for treatment of iron-deficiency anemia secondary to heavy uterine bleeding.
Selected Publications
How Dr. Banooni approaches fibroid patients
Diagnose precisely
Every treatment recommendation starts with clear imaging and an honest read of what your fibroids are actually doing.
Offer the least invasive option first
Surgery is recommended when it's the right tool for the job — not the default.
Explain the "why"
Patients leave consultations understanding their diagnosis and the reasoning behind their treatment plan, not just a list of instructions.
Schedule your consultation today.
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